Gene responsible for autism identified

The findings showed that alterations of the gene thousand and one amino-acid kinase 2, known as TAOK2, plays a direct role in these disorders.

IANS
Publish Date: Mar 6 2018 3:51PM | Updated Date: Mar 6 2018 3:57PM
Gene responsible for autism identifiedRepresentational Image

Scientists, including one of Indian-origin, have identified a gene that is responsible for neurodevelopmental disorders, including autism, an advance that may pave the way for developing treatments.

The findings showed that alterations of the gene thousand and one amino-acid kinase 2, known as TAOK2, plays a direct role in these disorders. 

TAOK2 is located in the autism spectrum disorder and schizophrenia-associated chromosomal deletion region and is associated with other neurodevelopmental phenotypes.

Many neurodevelopmental disorders are caused by large missing pieces of genetic material in a person's genome that contain several genes, termed a "microdeletion". 

Accurately diagnosing a gene microdeletion helps doctors to predict patient outcome and to determine if a new treatment is available, the study showed.

"Our studies reveal that in complex brain disorders that have a loss of many genes, a single deleted gene is sufficient to cause symptoms for the patients," said Karun Singh, assistant professor at McMaster University in Canada.

"This is exciting because it focuses our research effort on the individual gene, saving us time and money as it will speed up the development of targeted therapeutics to this gene alone," Singh added.

In the study, published in the journal Molecular Psychiatry, the team used genetically engineered models and computer algorithms to study a human genome, which allowed them to pinpoint the single gene in question.

The results revealed that alterations in TAOK2 activity contribute to neurodevelopmental disorders. TAOK2 KO mice showed several behavioural, anatomical and synaptic deficits consistent with other autistic mouse models. 

Moreover, the team also identified and characterised novel mutations in TAOK2 in human autism cohorts revealing that the mutations impact different signalling pathways.

"Our next step is to screen candidate drugs that correct the cognitive brain deficits caused by genetic mutations in TAOK2, and identify candidates for pilot clinical trials," Singh said.

Latest News

  1. Massive clashes erupt in HMT Srinagar after killing of ISJK chief in Anantnag gunfight
  2. Massive clashes erupt in HMT Srinagar after killing of ISJK chief in Anantnag gunfight
  1. DC Srinagar places 24 employees under suspension
  2. DC Srinagar places 24 employees under suspension
  1. 6th Sem polytechnic exam postponed
  2. 6th Sem polytechnic exam postponed
  1. Militants attack army vehicle in south Kashmir’s Pulwama
  2. Militants attack army vehicle in south Kashmir’s Pulwama
  1. Jammu and Kashmir officers posted in personal sections asked to go back to parent depts
  2. Jammu and Kashmir officers posted in personal sections asked to go back to parent depts
  1. JK Governor adviser Vijay Kumar reviews security situation in Kashmir
  2. JK Governor adviser Vijay Kumar reviews security situation in Kashmir
  1. Vohra holds all-party meet to discuss Jammu and Kashmir situation
  2. Vohra holds all-party meet to discuss Jammu and Kashmir situation
  1. Hizb ul Mujahideen owns Tral grenade attack
  2. Hizb ul Mujahideen owns Tral grenade attack
  1. 'Heartbroken' Messi fan in Kerala missing, suicide note found
  2. 'Heartbroken' Messi fan in Kerala missing, suicide note found
  1. Yashwant Sinha calls on NC vice president Omar Abdullah
  2. Yashwant Sinha calls on NC vice president Omar Abdullah
  1. Nine forces' personnel injured in Tral militant attack; Hizb claims responsibility
  2. Nine forces' personnel injured in Tral militant attack; Hizb claims responsibility
  1. New Delhi’s change of faces policy won’t make any difference in Kashmir: Mirwaiz
  2. New Delhi’s change of faces policy won’t make any difference in Kashmir: Mirwaiz
  1. Mehbooba Mufti meets Jammu and Kashmir Governor N N Vohra
  2. Mehbooba Mufti meets Jammu and Kashmir Governor N N Vohra
  1. First time since 1947, Sufi festival on Jammu and Kashmir border cancelled
  2. First time since 1947, Sufi festival on Jammu and Kashmir border cancelled
  1. Not inviting Er Rasheed to all-party meet exposes New Delhi: AIP
  2. Not inviting Er Rasheed to all-party meet exposes New Delhi: AIP
  1. JKLF protests against Srigufwara civilian killing
  2. JKLF protests against Srigufwara civilian killing
  1. Floral tributes paid to policeman killed in Karan Nagar militant attack
  2. Floral tributes paid to policeman killed in Karan Nagar militant attack
  1. Anantnag gunfight fallout: Shutdown, clashes in south Kashmir's Pulwama
  2. Anantnag gunfight fallout: Shutdown, clashes in south Kashmir's Pulwama
  1. BJP demands action against Azad for 'army operations killing more Kashmiri civilians' remark
  2. BJP demands action against Azad for 'army operations killing more Kashmiri civilians' remark
  1. Musharraf resigns as All Pakistan Muslim League chairman
  2. Musharraf resigns as All Pakistan Muslim League chairman
  1. ISJK chief Dawood Salafi among four militants killed in Anantnag gunfight: Police
  2. ISJK chief Dawood Salafi among four militants killed in Anantnag gunfight: Police
  1. Four militants among six killed in Anantnag gunfight; Internet suspended
  2. Four militants among six killed in Anantnag gunfight; Internet suspended
  1. Jammu and Kashmir govt makes biometric attendance compulsory for its employees
  2. Jammu and Kashmir govt makes biometric attendance compulsory for its employees
  1. Two more militants killed in Anantnag gunfight; toll six
  2. Two more militants killed in Anantnag gunfight; toll six
  1. EU launches retaliatory tariffs on US goods
  2. EU launches retaliatory tariffs on US goods
  1. Koreas discuss family reunion, humanitarian issues
  2. Koreas discuss family reunion, humanitarian issues
  1. Mobile Internet services snapped in three Kashmir districts
  2. Mobile Internet services snapped in three Kashmir districts
  1. Tral shuts on third consecutive day to mourn militant killings
  2. Tral shuts on third consecutive day to mourn militant killings
  1. Ganderbal: Rescue operation to trace drowned teacher continues on third straight day
  2. Ganderbal: Rescue operation to trace drowned teacher continues on third straight day
  1. Two militants killed in ongoing Anantnag gunfight
  2. Two militants killed in ongoing Anantnag gunfight
  1. More than 1,000 migrants drowned in Mediterranean in 2018: UN
  2. More than 1,000 migrants drowned in Mediterranean in 2018: UN
  1. Police constable injured in Karan Nagar militant attack succumbs
  2. Police constable injured in Karan Nagar militant attack succumbs
  1. Gunfight breaks out in south Kashmir’s Anantnag
  2. Gunfight breaks out in south Kashmir’s Anantnag
x
This site uses cookies to deliver our services and to show you relevant news and ads. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Service.That's Fine